- 1971 - Project P.A.W. was incorporated as a 501(c)(3) not-for-profit charity. Previously, the local solution to the problem of abandoned kittens and cats was euthanasia in carbon monoxide chambers.
- 1972 - A group of concerned women began fundraising efforts, including bake sales, garage sales, and flea markets. They began sheltering the animals in their homes, and placing them with adoptive families.
- 1976 - Project P.A.W. member Janet Ainey purchased and donated the current shelter building at 127 Bevier Street. The building was previously a paint warehouse.
- 1976 - Project P.A.W. and a group of concerned veterinarians created the first low-cost spay/neuter program in the Greater Binghamton area.
- 2003 - Longtime Project P.A.W. Director Donna Kocan passed away unexpectedly.
- 2005 - Project P.A.W. web site was launched.
- 2013 - Many important renovations were implemented inside the shelter.